Geranylated flavanones from Paulownia coreana and their inhibitory effects on nitric oxide production.
نویسندگان
چکیده
The activity-guided fractionation of the MeOH extract of the flower of Paulownia coreana led to the isolation of a new geranylated flavanone, 3'-O-methyl-5'-hydroxydiplacol (1), along with 10 known compounds (2-11). Their structures were determined using spectroscopic techniques, which included one and two dimensional (1- and 2D)-NMR. Among the isolates, compounds 1-6 showed potent inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide production with IC50 values ranging 1.48 to 16.66 µM.
منابع مشابه
Lee et al., Inhibitory effect and mechanism of antiproliferation of isoatriplicolide tiglate (PCAC) from Paulownia Coreana. Molecules 2012, 17, 5945-5951: a note regarding Paulownia coreana.
I read with interest the article by Lee et al. entitled " Inhibitory Effect and Mechanism of Antiproliferation of Isoatriplicolide Tiglate (PCAC) from Paulownia Coreana " [1]. This article is quite interesting and the authors should be complimented for the significant amount of work they have done. The purpose of this letter is to call attention to the need for some clarification on the name of...
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متن کاملResponse to Wiart, C. Lee et al., Inhibitory effect and mechanism of antiproliferation of isoatriplicolide tiglate (PCAC) from Paulownia coreana. Molecules 2012, 17, 5945-5951: a note regarding Paulownia coreana. Molecules 2013, 18, 2587-2588.
In a Comment recently published in Molecules [1], Prof. C. Wiart took issue with our identification of the plant species used in our work as Paulownia coreana. Although this name was assigned by H. Uyeki in 1925 [2], appears as such in handbooks of Korean flora [3], and examples of its use can be found in the recent literature [4–9], after reviewing the arguments and references presented in [1]...
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ورودعنوان ژورنال:
- Chemical & pharmaceutical bulletin
دوره 63 5 شماره
صفحات -
تاریخ انتشار 2015